The remaining three types of endometrial carcinoma have a poor prognosis . Approximately 15 percent of women have adenosquamous carcinoma, in which both the gland cells and squamous cells are malignant . Three percent have a clear cell carcinoma, and about 1 percent have a papillary carcinoma.
Uterine sarcoma is another kind of uterine malignancy. ( See "Uterus: Uterine Sarcomas." )
How It Spreads From where it arises in the lining of the uterus , endometrial carcinoma may invade the wall of the uterus and may spread to the cervix . It can also spread to other structures in the pelvis including the fallopian tubes, ovaries, bladder, vagina and rectum ( see Cancers of female pelvic organs ).
It can also spread by the lymphatic system to the pelvic and aortic lymph nodes and to the lymph nodes in the groin and above the collarbone (supraclavicular). Like ovarian carcinoma, endometrial cancer can also spread throughout the abdominal cavity and occasionally through the bloodstream to the lung, liver and brain.
Endometrial cancer is occasionally associated with a primary carcinoma of the ovary. ( See "Ovary." )
